Design of allele-specific inhibitors to probe protein kinase signaling
نویسندگان
چکیده
منابع مشابه
Design of allele-specific inhibitors to probe protein kinase signaling
BACKGROUND Deconvoluting protein kinase signaling pathways using conventional genetic and biochemical approaches has been difficult because of the overwhelming number of closely related kinases. If cell-permeable inhibitors of individual kinases could be designed, the role of each kinase could be systematically assessed. RESULTS We have devised an approach combining chemistry and genetics to ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70198-8